<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
  <model id="Model_1" name="Model 1: one path">
    <listOfFunctionDefinitions>
      <functionDefinition id="function_1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> substrate </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> V </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> substrate </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> substrate </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_0">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> enzyme </ci>
            </bvar>
            <bvar>
              <ci> substrate </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> enzyme </ci>
                <ci> substrate </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> substrate </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_BRafActivationByRas">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> BRaf </ci>
            </bvar>
            <bvar>
              <ci> Ras </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> Ras </ci>
                <ci> BRaf </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> BRaf </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_MEKactivation2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> BRafPP </ci>
            </bvar>
            <bvar>
              <ci> species_9 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> BRafPP </ci>
                <ci> species_9 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_9 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_BRafActivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> activeRap1 </ci>
            </bvar>
            <bvar>
              <ci> BRaf </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> activeRap1 </ci>
                <ci> BRaf </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> BRaf </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_Rap1Deactivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> activeRap1 </ci>
            </bvar>
            <bvar>
              <ci> species_23 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_23 </ci>
                <ci> activeRap1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> activeRap1 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_Rap1ActivationByEPAC">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_17 </ci>
            </bvar>
            <bvar>
              <ci> inactiveRap1 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_17 </ci>
                <ci> inactiveRap1 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> inactiveRap1 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_EPACActivation2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Cilostamide </ci>
            </bvar>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_18 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> Cilostamide </ci>
                <ci> species_18 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_18 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_EPACActivation1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> EPACA </ci>
            </bvar>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_18 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> EPACA </ci>
                <ci> species_18 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_18 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_PKAactivation2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Cilostamide </ci>
            </bvar>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_16 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> Cilostamide </ci>
                <ci> species_16 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_16 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_PKAActivation1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> PKAA </ci>
            </bvar>
            <bvar>
              <ci> species_16 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> PKAA </ci>
                <ci> species_16 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_16 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_cRafInhibition">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_14 </ci>
            </bvar>
            <bvar>
              <ci> cRaf </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_14 </ci>
                <ci> cRaf </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_activeSosInhibition">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> ERKPP </ci>
            </bvar>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_3 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> ERKPP </ci>
                <ci> species_3 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_3 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_SosInhibition">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> ERKPP </ci>
            </bvar>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_4 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> ERKPP </ci>
                <ci> species_4 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_4 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_ERKactivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_10 </ci>
            </bvar>
            <bvar>
              <ci> species_11 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_10 </ci>
                <ci> species_11 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_11 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_MEKactivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> cRafPP </ci>
            </bvar>
            <bvar>
              <ci> species_9 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> cRafPP </ci>
                <ci> species_9 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_9 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_cRafActivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> Ras </ci>
            </bvar>
            <bvar>
              <ci> cRaf </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> Ras </ci>
                <ci> cRaf </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_RasDeactivation1">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_23 </ci>
            </bvar>
            <bvar>
              <ci> Ras </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_23 </ci>
                <ci> Ras </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> Ras </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_RasActivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_3 </ci>
            </bvar>
            <bvar>
              <ci> species_6 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_3 </ci>
                <ci> species_6 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_6 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_2">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> substrate </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> V </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> V </ci>
                <ci> substrate </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> substrate </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
      <functionDefinition id="function_4_SosActivation">
        <math xmlns="http://www.w3.org/1998/Math/MathML">
          <lambda>
            <bvar>
              <ci> Kcat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> species_1 </ci>
            </bvar>
            <bvar>
              <ci> species_4 </ci>
            </bvar>
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> Kcat </ci>
                <ci> species_1 </ci>
                <ci> species_4 </ci>
              </apply>
              <apply>
                <plus/>
                <ci> Km </ci>
                <ci> species_4 </ci>
              </apply>
            </apply>
          </lambda>
        </math>
      </functionDefinition>
    </listOfFunctionDefinitions>
    <listOfUnitDefinitions>
      <unitDefinition id="volume">
        <listOfUnits>
          <unit kind="litre" scale="-3" multiplier="1" offset="0"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="substance">
        <listOfUnits>
          <unit kind="mole" scale="-3" multiplier="1" offset="0"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment id="compartment_0" name="cell" size="1"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="EGF" name="EGF" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_1" name="boundEGFR" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_2" name="unboundEGFR" compartment="compartment_0" initialConcentration="500"/>
      <species id="species_3" name="activeSos" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_4" name="inactiveSos" compartment="compartment_0" initialConcentration="1200"/>
      <species id="Ras" name="activeRas" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_6" name="inactiveRas" compartment="compartment_0" initialConcentration="1200"/>
      <species id="cRaf" name="cRaf" compartment="compartment_0" initialConcentration="1500"/>
      <species id="cRafPP" name="cRafPP" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_9" name="MEK" compartment="compartment_0" initialConcentration="3000"/>
      <species id="species_10" name="MEKPP" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_11" name="ERK" compartment="compartment_0" initialConcentration="10000"/>
      <species id="ERKPP" name="ERKPP" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_13" name="removedSos" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_14" name="PKA" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_15" name="removedcRaf" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_16" name="inactivePKA" compartment="compartment_0" initialConcentration="1000"/>
      <species id="species_17" name="EPAC" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_18" name="inactiveEPAC" compartment="compartment_0" initialConcentration="1000"/>
      <species id="activeRap1" name="activeRap1" compartment="compartment_0" initialConcentration="0"/>
      <species id="inactiveRap1" name="inactiveRap1" compartment="compartment_0" initialConcentration="1200"/>
      <species id="activeC3G" name="activeC3G" compartment="compartment_0" initialConcentration="0"/>
      <species id="C3G" name="inactiveC3G" compartment="compartment_0" initialConcentration="0"/>
      <species id="BRaf" name="BRaf" compartment="compartment_0" initialConcentration="1500"/>
      <species id="BRafPP" name="BRafPP" compartment="compartment_0" initialConcentration="0"/>
      <species id="species_23" name="Gap" compartment="compartment_0" initialConcentration="2400" boundaryCondition="true" constant="true"/>
      <species id="EPACA" name="EPACA" compartment="compartment_0" initialConcentration="0" boundaryCondition="true" constant="true"/>
      <species id="Cilostamide" name="Cilostamide" compartment="compartment_0" initialConcentration="0" boundaryCondition="true" constant="true"/>
      <species id="PKAA" name="PKAA" compartment="compartment_0" initialConcentration="0" boundaryCondition="true" constant="true"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="Noise1" value="336.39824"/>
      <parameter id="Noise2" value="724.02509"/>
      <parameter id="Noise3" value="806.04144"/>
      <parameter id="Noise4" value="234.68895"/>
      <parameter id="Noise5" value="412.0203"/>
      <parameter id="Noise6" value="1390.8738"/>
      <parameter id="Noise7" value="334.80612"/>
      <parameter id="Noise8" value="2369.829"/>
      <parameter id="Noise9" value="2496.8866"/>
      <parameter id="Noise10" value="898.20384"/>
      <parameter id="Noise11" value="376.69411"/>
      <parameter id="Noise12" value="422.03675"/>
      <parameter id="Noise13" value="466.92148"/>
      <parameter id="Noise14" value="756.81122"/>
      <parameter id="Noise15" value="652.62914"/>
      <parameter id="Noise16" value="433.05263"/>
      <parameter id="Noise17" value="157.05861"/>
      <parameter id="Noise18" value="2599.1235"/>
      <parameter id="Noise19" value="68.837148"/>
      <parameter id="Noise20" value="1517.438"/>
      <parameter id="Noise21" value="508.2347"/>
      <parameter id="Noise22" value="396.4843"/>
      <parameter id="Noise23" value="248.99591"/>
      <parameter id="Noise24" value="3055.4155"/>
      <parameter id="Noise25" value="2200.2508"/>
      <parameter id="Noise26" value="898.48305"/>
      <parameter id="Noise27" value="2232.7284"/>
      <parameter id="Noise28" value="1183.1793"/>
      <parameter id="Noise29" value="156.79084"/>
      <parameter id="Noise30" value="1018.7543"/>
      <parameter id="Noise31" value="1392.0447"/>
      <parameter id="Noise32" value="2725.2497"/>
      <parameter id="Noise33" value="2425.8872"/>
      <parameter id="Noise34" value="598.76962"/>
      <parameter id="Noise35" value="428.25663"/>
      <parameter id="Noise36" value="1032.756"/>
      <parameter id="Noise37" value="755.76971"/>
      <parameter id="Noise38" value="1071.0804"/>
      <parameter id="Noise39" value="2512.2948"/>
      <parameter id="Noise40" value="479.36865"/>
      <parameter id="Noise41" value="224.31902"/>
      <parameter id="Noise42" value="512.25201"/>
      <parameter id="Noise43" value="6715.7529"/>
      <parameter id="Noise44" value="2383.1146"/>
      <parameter id="Noise45" value="2649.0268"/>
      <parameter id="Noise46" value="101.15337"/>
      <parameter id="Noise47" value="200.76537"/>
      <parameter id="SosKcat" value="0.00026734056"/>
      <parameter id="SosKm" value="6549.9295"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="reaction_0" name="SosActivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_3"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_1"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_SosActivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_1 </ci>
                <ci> species_4 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="3.1143989"/>
            <parameter id="Km" value="15859.286"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_1" name="EGFBingingToTheReceptor (forward)" reversible="false">
        <listOfReactants>
          <speciesReference species="EGF"/>
          <speciesReference species="species_2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <ci> k1 </ci>
              <ci> EGF </ci>
              <ci> species_2 </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" value="1.0413027"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_2" name="EGFBingingToTheReceptor (backward)" reversible="false">
        <listOfReactants>
          <speciesReference species="species_1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="EGF"/>
          <speciesReference species="species_2"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <ci> k1 </ci>
              <ci> species_1 </ci>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="k1" value="8674.8974"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_3" name="SosDeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_4"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> species_3 </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="12414.394"/>
            <parameter id="V" value="105.11213"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_4" name="RasActivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_6"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Ras"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_3"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_RasActivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_3 </ci>
                <ci> species_6 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="11.879147"/>
            <parameter id="Km" value="9409.6448"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_5" name="RasDeactivation1" reversible="false">
        <listOfReactants>
          <speciesReference species="Ras"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_6"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_23"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_RasDeactivation1 </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_23 </ci>
                <ci> Ras </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="21.135069"/>
            <parameter id="Km" value="10066.445"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_6" name="cRafActivation" reversible="false">
        <listOfReactants>
          <speciesReference species="cRaf"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="cRafPP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Ras"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_cRafActivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> Ras </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="0.64793755"/>
            <parameter id="Km" value="5416.0786"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_7" name="cRafDeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="cRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="cRaf"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> cRafPP </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="1150.5828"/>
            <parameter id="V" value="7279.2518"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_8" name="MEKactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_9"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_10"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="cRafPP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_MEKactivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> cRafPP </ci>
                <ci> species_9 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="3.0837466"/>
            <parameter id="Km" value="16537.206"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_9" name="MEKdeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_10"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_9"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> species_10 </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="4623.9663"/>
            <parameter id="V" value="9492.581"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_10" name="ERKactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_11"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="ERKPP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_10"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_ERKactivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_10 </ci>
                <ci> species_11 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="11.26511"/>
            <parameter id="Km" value="178.19406"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_11" name="SosInhibition" reversible="false">
        <listOfReactants>
          <speciesReference species="species_4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_13"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ERKPP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_SosInhibition </ci>
                <ci> ERKPP </ci>
                <ci> SosKcat </ci>
                <ci> SosKm </ci>
                <ci> species_4 </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_12" name="activeSosInhibition" reversible="false">
        <listOfReactants>
          <speciesReference species="species_3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_13"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ERKPP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_activeSosInhibition </ci>
                <ci> ERKPP </ci>
                <ci> SosKcat </ci>
                <ci> SosKm </ci>
                <ci> species_3 </ci>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_13" name="cRafInhibition" reversible="false">
        <listOfReactants>
          <speciesReference species="cRaf"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_15"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_14"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_cRafInhibition </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_14 </ci>
                <ci> cRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="9.0566519"/>
            <parameter id="Km" value="2187.4476"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_14" name="PKAActivation1" reversible="false">
        <listOfReactants>
          <speciesReference species="species_16"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_14"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="PKAA"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_PKAActivation1 </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> PKAA </ci>
                <ci> species_16 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="3.3699259"/>
            <parameter id="Km" value="2719.8902"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_15" name="PKAactivation2" reversible="false">
        <listOfReactants>
          <speciesReference species="species_16"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_14"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Cilostamide"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_PKAactivation2 </ci>
                <ci> Cilostamide </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_16 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="9.7135445"/>
            <parameter id="Km" value="7226.424"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_16" name="PKADeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_14"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_16"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> species_14 </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="1440.2974"/>
            <parameter id="V" value="11407.073"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_17" name="EPACActivation1" reversible="false">
        <listOfReactants>
          <speciesReference species="species_18"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_17"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="EPACA"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_EPACActivation1 </ci>
                <ci> EPACA </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="14.38707"/>
            <parameter id="Km" value="12638.587"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_18" name="EPACActivation2" reversible="false">
        <listOfReactants>
          <speciesReference species="species_18"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_17"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Cilostamide"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_EPACActivation2 </ci>
                <ci> Cilostamide </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_18 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="22.893191"/>
            <parameter id="Km" value="9223.1488"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_19" name="EPACDeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="species_17"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_18"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> species_17 </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="8611.4427"/>
            <parameter id="V" value="3374.585"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_20" name="Rap1ActivationByEPAC" reversible="false">
        <listOfReactants>
          <speciesReference species="inactiveRap1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="activeRap1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_17"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_Rap1ActivationByEPAC </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> species_17 </ci>
                <ci> inactiveRap1 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="1.5811275"/>
            <parameter id="Km" value="9503.8729"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_21" name="Rap1Deactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="activeRap1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="inactiveRap1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="species_23"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_Rap1Deactivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> activeRap1 </ci>
                <ci> species_23 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="4.6958251"/>
            <parameter id="Km" value="1870.8648"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_22" name="BRafActivation" reversible="false">
        <listOfReactants>
          <speciesReference species="BRaf"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRafPP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="activeRap1"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_BRafActivation </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> activeRap1 </ci>
                <ci> BRaf </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="5.4803675"/>
            <parameter id="Km" value="10486.48"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_23" name="BRafDeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="BRafPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRaf"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> BRafPP </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="3559.6036"/>
            <parameter id="V" value="5519.4767"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_24" name="MEKactivation2" reversible="false">
        <listOfReactants>
          <speciesReference species="species_9"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_10"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="BRafPP"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_MEKactivation2 </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> BRafPP </ci>
                <ci> species_9 </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="6.2146831"/>
            <parameter id="Km" value="6708.8306"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_25" name="BRafActivationByRas" reversible="false">
        <listOfReactants>
          <speciesReference species="BRaf"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="BRafPP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="Ras"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_4_BRafActivationByRas </ci>
                <ci> Kcat </ci>
                <ci> Km </ci>
                <ci> BRaf </ci>
                <ci> Ras </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Kcat" value="5.7324196"/>
            <parameter id="Km" value="10284.924"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
      <reaction id="reaction_26" name="ERKdeactivation" reversible="false">
        <listOfReactants>
          <speciesReference species="ERKPP"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="species_11"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> compartment_0 </ci>
              <apply>
                <ci> function_2 </ci>
                <ci> ERKPP </ci>
                <ci> Km </ci>
                <ci> V </ci>
              </apply>
            </apply>
          </math>
          <listOfParameters>
            <parameter id="Km" value="43.802107"/>
            <parameter id="V" value="733.74749"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
