Modelling the effects of serotonin on the hippocampal CA1 region during navigation

Allan, Jon (2018) Modelling the effects of serotonin on the hippocampal CA1 region during navigation. PhD thesis, University of Glasgow.

Abstract

The mammalian hippocampus is vitally involved in the formation of both episodic memory and semantic memory, and in learning and recognition. These functions are actively involved during spatial navigation through an environment. The rodent hippocampus in particular has been greatly studied, providing a wealth of experimental data; however collation of this data into universally accepted theories of hippocampal function is far from complete. The present study concentrates on events occurring in the rodent hippocampus during such navigation. There is particular emphasis on the hippocampal theta rhythm which is manifested during navigation; on the existence and characteristics of place fields and associated place cells; and on the phenomenon of phase precession. The study has been limited to the CA1 region. Testable assertions are made about these phenomena. These assertions have been incorporated into models which are described in the later chapters of the thesis. The model has been further extended to demonstrate features of serotonergic activity in the CA1 region.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Hippocampus CA1, seritonin.
• Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Colleges/Schools: College of Science and Engineering > School of Engineering
• Supervisor's Name: Porr, Dr. Bernd
• Date of Award: 2018
• Depositing User: Dr. Jon Allan
• Unique ID: glathesis:2018-9090
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 23 May 2018 09:11
• Last Modified: 20 Jun 2018 10:00
• URI: https://theses.gla.ac.uk/id/eprint/9090