The influence of liver function on the adrenolytic and carcinogenic action of 9,10-dimethyl-1,2 benzanthracene

Kernohan, Ian Riddell (1971) The influence of liver function on the adrenolytic and carcinogenic action of 9,10-dimethyl-1,2 benzanthracene. Ch.M thesis, University of Glasgow.

Abstract

This Thesis imports a series of investigations into the carcinogenic and adrenolytic effect of the polycyclic hydrocarbon 9;10-dimethyl-1;2-benzanthracene in the Sprague Dawley rat. The results of the investigations support the hypothesis that the caroinogenic effect is due to 9;10-dimethyl-1;2-benzanthracene itself, whereas the adrenolytic action is produced by a metabolite of the hydrocarbon. AS hepatic damage was shown to protect the adrenal glands against necrosis it appears that the metabolic conversion of 9;10-dimethyl-1;2-benzanthracene to an adrenolytic derivative is a function of the liver. In order to assess degrees of liver damage a liver function test was developed based on the duration of Nembutal narcosis. It was found that there was correlation between the degree of liver damage produced and the ability to protect the adrenal glands by various protective measures.

• Item Type: Thesis (Ch.M)
• Qualification Level: Masters
• Additional Information: Adviser: A R Currie
• Keywords: Toxicology, Biochemistry
• Date of Award: 1971
• Depositing User: Enlighten Team
• Unique ID: glathesis:1971-72925
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 11 Jun 2019 11:06
• Last Modified: 11 Jun 2019 11:06
• URI: https://theses.gla.ac.uk/id/eprint/72925