Studies of Isocitrate Dehydrogenase From Bacillus caldotenax

Wild, Catherine Margaret (1992) Studies of Isocitrate Dehydrogenase From Bacillus caldotenax. PhD thesis, University of Glasgow.

Abstract

Most micro-organisms contain an NADP-dependent isocitrate dehydrogenase (ICDH) activity. During growth of micro-organisms on acetate as the sole carbon source the two enzymes of the glyoxylate bypass, isocitrate lyase (ICL) and malate synthase (MS), are induced. These two enzymes are required to generate the intermediates of the TCA cycle that are used for biosynthesis. Under these conditions there is competition between the TCA cycle enzyme ICDH and the glyoxylate bypass enzyme ICL for available isocitrate. In E. coli this competition is overcome by the partial phosphorylation and inactivation of ICDH. This mechanism of control has been observed in other enteric bacteria.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Hugh G Nimmo
• Keywords: Biochemistry
• Date of Award: 1992
• Depositing User: Enlighten Team
• Unique ID: glathesis:1992-74608
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 13 Nov 2019 15:58
• Last Modified: 13 Nov 2019 15:58
• URI: https://theses.gla.ac.uk/id/eprint/74608