Interaction of alpha2-Adrenergic Receptors With G-Proteins

McClue, Steven J (1991) Interaction of alpha2-Adrenergic Receptors With G-Proteins. PhD thesis, University of Glasgow.

Abstract

A wide variety of hormones and neurotransmitters have been shown to produce intracellular signals mediated by guanine-nucleotide binding proteins (G-proteins). These have been shown to form a link between receptors on the extracellular face of the cell membrane, and their intracellular second-message-generating effectors, such as phospholipase C and adenylyl cyclase. An increasing number of different heterotrimeric G-proteins have been isolated, with varying degrees (50-95%) of sequence homology. This similarity of sequence has raised questions of specificity of interaction of G-proteins: do individual G-proteins interact only with specific receptors and effectors, or are they more promiscuous in their interaction? This question has been addressed by examining the specificity of coupling of G-proteins to alpha2-adrenergic receptors in two model systems.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Biochemistry, Molecular biology
• Date of Award: 1991
• Depositing User: Enlighten Team
• Unique ID: glathesis:1991-77092
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:20
• Last Modified: 14 Jan 2020 09:20
• URI: https://theses.gla.ac.uk/id/eprint/77092