The Modulation of the Phenotype of Human-Non-Small Cell Lung Cancer

McLean, John S (1986) The Modulation of the Phenotype of Human-Non-Small Cell Lung Cancer. PhD thesis, University of Glasgow.

Abstract

The effect of dexamethasone on human non-small cell lung carcinoma in vitro and in vivo was investigated. Dexamethasone caused a significant reduction in growth rate in most of the cell lines at normal passage densities with the exception of H125 which had an increased growth rate in the presence of dexamethasone. In both cases the effect was dose dependent. Clonogenicity as a monolayer was increased by dexamethasone in all cell lines investigated except H125. Cloning efficiency in agar of all the cell lines examined was reduced by dexamethasone in a dose dependant manner. Significant levels of glucocorticoid receptor were found in all cell lines investigated. PA activity was lowered by dexamethasone in all cell lires except H125 where it was raised though not significantly.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Medicine, Oncology, Pharmacology
• Date of Award: 1986
• Depositing User: Enlighten Team
• Unique ID: glathesis:1986-77250
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:14
• Last Modified: 14 Jan 2020 09:14
• URI: https://theses.gla.ac.uk/id/eprint/77250