Studies in Experimental Hypertension and the Renin-Angiotensin System

Wallace, Elisabeth Carol Hislop (1988) Studies in Experimental Hypertension and the Renin-Angiotensin System. MSc(R) thesis, University of Glasgow.

Abstract

Blood pressure, angiotensin II and renin content were measured in unanaesthetized two-kidney, one clip hypertensive rats at 1 and 2 days, at weekly intervals up to 10 weeks and at 15 and 20 weeks after clipping. Blood pressure was elevated at 1-2 days and remained at this level until 2 weeks when there was a further progressive rise reaching a plateau at 5-6 weeks after which time hypertension was sustained up to 20 weeks. Compared with values in sham-operated rats angiotensin II and renin were initially increased at 1-2 days but were then supressed between 2 and 4 weeks to levels similar to those found in the sham-operated rats. Between 5 and 20 weeks angiotensin II and renin increased again to high levels. There was a significant correlation between angiotensin II and blood pressure in acute rats 1-2 days after clipping (p<0.05) and in chronic rats 8-20 weeks after clipping (p<0.001). There was no difference in the slope of the regression lines but the regression line for the chronic rats was shifted upwards in a parallel manner.

• Item Type: Thesis (MSc(R))
• Qualification Level: Masters
• Keywords: Medicine, Physiology
• Date of Award: 1988
• Depositing User: Enlighten Team
• Unique ID: glathesis:1988-77270
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:13
• Last Modified: 14 Jan 2020 09:13
• URI: https://theses.gla.ac.uk/id/eprint/77270