The Haemolysis of Human Erythrocytes in Relation to the Lattice Structure of Water

Good, William (1954) The Haemolysis of Human Erythrocytes in Relation to the Lattice Structure of Water. PhD thesis, University of Glasgow.

Abstract

1. An investigation has been made of the haemolysis of human erythrocytes in hypotonic solutions of malonamide and other organic substances. 2. It has been found that the Arrhenius equation adequately describes the effect of temperature on all the haemolytic systems Investigated. 3. Electrolytes do not inhibit malonamide haemolysis to the same degree,when present in osmotically equivalent concentrations. 4. Non-penetrating non-electrolytes do not inhibit malonamide haemolysis to the same degree,when present in osmotically equivalent concentrations. 5. Interpretation of the terms of the Arrhenius equation with respect to the haemolytic process, the effects of electrolytes and the effects of non-electrolytes, have led to the conclusion that the lattice structure of water is of prime importance in haemolysis. 6. The inhibition due to ions depends on their size and the magnitude of the electrostatic effect which they exert on the water lattice. 7. The inhibition due to non-penetrating non electrolytes depends on their great strengthening action on the water lattice. 8. Of the organic substances investigated, those that penetrate slowly are likely to strengthen the water lattice, while those that penetrate rapidly are unlikely to strengthen the water lattice.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Physiology
• Date of Award: 1954
• Depositing User: Enlighten Team
• Unique ID: glathesis:1954-79083
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 31 Mar 2020 09:09
• Last Modified: 31 Mar 2020 09:09
• URI: https://theses.gla.ac.uk/id/eprint/79083