Endocrine Factors in Experimental Peptic Ulcer and Hypertension

Crane, W. A. J (1959) Endocrine Factors in Experimental Peptic Ulcer and Hypertension. MD thesis, University of Glasgow.

Abstract

This thesis is divided into six parts:- Part I is concerned with the peptic ulcers which develop in rabbits following the administration of pitressin. Histological and arteriographic studies establish the pathogenesis of the gastric lesions, and an increase in adrenal cortical function is suggested on the basis of a bio-assay method. Part II shows that pitressin peptic ulcers in rabbits and rats are aggravated by the simultaneous administration of cortisone or corticotrophin. Ulcers are more numerous, some perforate, and bacterial invasion is increased. Similar lesions are produced both in the presence and absence of the adrenal glands. Part III is concerned with the concept that stimulation of the pituitary and adrenal glands during stress produces ''diseases of adaptation" in the sensitized (unilateral nephrectomy and increased sodium chloride intake) rat. Following exposure to cold stress peptic ulcer is not found, but hypertension develops. It is shown that the hypertension is not the result of increased adrenal cortical function following cold exposure, but is closely related to the increased consumption of sodium chloride. Part IV is an investigation of the pathological effects of several different stressors on sensitized rats. Mild hypertension develops in very few animals and there is no voluntary increase in the consumption of sodium chloride diet. Part V demonstrates the hypertensive pathological effects of sodium-retaining steroids. It is shown that similar lesions can he produced by sodium chloride administration without hormone overdosage. The role of the kidney in this hypertensive syndrome is established and it is shown that the adrenal glands or the cortical hormones are not essential for its development. Part VI is a study of the hypertension associated with the regeneration of adrenal cortical tissue in sensitized rats. Factors relating to the pathogenesis of this syndrome are elucidated by modifying the sodium chloride intake of the animals, and by transplantation experiments in which the regenerating adrenal tissue is transplanted into different areas drained by the portal and systemic circulation. The text is presented in Volume I and the illustrations in Volume II. An Appendix of technical methods is included in Volume I.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Endocrinology
• Date of Award: 1959
• Depositing User: Enlighten Team
• Unique ID: glathesis:1959-79304
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 05 Mar 2020 11:00
• Last Modified: 05 Mar 2020 11:00
• URI: https://theses.gla.ac.uk/id/eprint/79304