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The electrophysiological effects of Endothelin-1 in human atrial myocytes

Redpath, Calum J. (2009) The electrophysiological effects of Endothelin-1 in human atrial myocytes. PhD thesis, University of Glasgow.

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Abstract

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5 µM significantly increased peak ICaL from -4.7± 0.4 to -12.2± 0.9 pA/pF (P<
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on potential duration at 50% repolarisation (APD50) from 30± 7 to 46± 7 ms (P<
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ese adrenergic effects on APD50 and SDs were also abolished by ET-1 at 10 nM (P<
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ISO at 0.05 µM produced spontaneous depolarisations in 5 of 7 cells studied (P<
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 test). Endothelin-1 at 10 nM abolished these depolarisations in all 5 cells (P<
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was associated with spontaneous depolarisations in significantly fewer cells (P<
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Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: human atrium, arrhythmogenesis, electrophysiology, L-type calcium current, ICaL, action potentials, nystatin perforated patch clamp, endothelin, neurohormones, isoproterenol
Subjects: R Medicine > RM Therapeutics. Pharmacology
Q Science > QP Physiology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Rankin, Prof Andrew C.
Date of Award: 2009
Depositing User: Dr Calum J Redpath
Unique ID: glathesis:2009-1164
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 01 Oct 2009
Last Modified: 10 Dec 2012 13:35
URI: http://theses.gla.ac.uk/id/eprint/1164

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