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Intestinal absorption and bioavailability of coffee phenolics and green tea polyphenols: a study in healthy and ileostomy volunteers

Stalmach, Angelique (2009) Intestinal absorption and bioavailability of coffee phenolics and green tea polyphenols: a study in healthy and ileostomy volunteers. PhD thesis, University of Glasgow.

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Abstract

Flavonoids and phenolic compounds (aka polyphenols) are phytochemicals, thought to participate in plant development and defence mechanisms. Polyphenols are ubiquitous plant secondary metabolites, and are usually found conjugated as glycosides or esters. These compounds have been of particular interest as part of the human diet, and have been the focus os many studies in nutrition research. Many epidemological studies have found a correlation between flavonoid intake and protection against certain chronic diseases such as cancer and cardiovascular events. The mechanisms underlying such benefits, however, remain to be unveiled, as judged by the number of in vitro and animal model intervention studies. The primary property attributed to polyphenolic and phenolic compounds relates to their antioxidant activities. Outcome from in vitro studies have established the ability of polyphenols to scavenge radical species and bind to metal ions, thus preventing the damage caused by oxidative stress. Recent progress in the field has broadened the knowledge of how polyphenols exert their beneficial effects, which appears to depend on more than simply antioxidant activity. Indeed, polyphenols are thought to actively participate in the modulatory effects involved in signal transduction in cells, responsible for the regulation of genes, apoptosis and cell proliferation.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Due to copyright restrictions the full text of this thesis cannot be made available online. Access to the printed version is available once any embargo periods have expired.
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Colleges/Schools: College of Medical Veterinary and Life Sciences
Supervisor's Name: Crozier, Prof. Alan
Date of Award: 2009
Depositing User: Mrs Marie Cairney
Unique ID: glathesis:2009-1241
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 16 Oct 2009
Last Modified: 07 Feb 2014 10:31
URI: http://theses.gla.ac.uk/id/eprint/1241

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