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Studies of aldosterone renin ratio and genetic variation at the CYP11B1/CYP11B2 locus in human essential hypertension

Alvarez-Madrazo, Samantha (2010) Studies of aldosterone renin ratio and genetic variation at the CYP11B1/CYP11B2 locus in human essential hypertension. PhD thesis, University of Glasgow.

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Abstract

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L per mIU/L (range 0.04-253.16). The majority of subjects (> 80%) had an ARR   <
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tively and ARR positively associated with ambulatory blood pressure readings (p<
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subjects not taking antihypertensives. The heritability of the ARR was 38.1% (p<
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e heritability of renin and aldosterone was 27.4% and 28.7% respectively with p<
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nt differences were in the following SNP: rs4313136 (-1889G/T) and rs6471580, p<
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(-1889G/T) and rs6471580, p<0.05; rs4736354, rs4546 and rs1799998 (-344T/C), p.<
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54, rs4546 and rs1799998 (-344T/C), p.<0.01 and rs5283 and intron conversion, p<
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Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Chapter 4 in this thesis has been published in the Journal of Clinical Endocrinology and Metabolism. Edited version of the thesis has been uploaded, with 3rd party copyright material removed.
Keywords: hypertension, aldosterone, aldosterone renin ratio, CYP11B1, CYP11B2
Subjects: R Medicine > RC Internal medicine
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Connell, Prof. John and Eleanor, Prof. Davies
Date of Award: 2010
Depositing User: Miss Samantha Alvarez-Madrazo
Unique ID: glathesis:2010-1451
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 15 Mar 2010
Last Modified: 11 Apr 2013 14:05
URI: http://theses.gla.ac.uk/id/eprint/1451

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