Flores-Muñoz, Monica (2010) Investigating the role of Angiotensin 1-9 in cardiomyocytes hypertrophy. PhD thesis, University of Glasgow.Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.
The renin-angiotensin system (RAS) regulates blood pressure, and homeostasis through angiotensin II (AngII). Angiotensin converting enzyme 2 (ACE2), a homologue of ACE, metabolizes AngII to Ang1-7. Ang1-7 antagonizes AngII via the receptor MAS. ACE2 also converts AngI to Ang1-9. Very little is known about Ang1-9 although it is thought to be a substrate for Ang1-7 generation via ACE. We investigated Ang1-9 and Ang1-7 function in cardiomyocyte hypertrophy in rat neonatal and primary adult rabbit left ventricular cardiomyocytes. We have shown that Ang1-7 and Ang1-9 blocked AngII-induced hypertrophy. Furthermore, we demonstrated an independent role of Ang1-9 in cardiac hypertrophy and generated evidence that Ang1-9 signals via the angiotensin type 2 receptor. In vivo we delivered Ang1-9 via osmotic minipumps for 4 weeks into stroke-prone spontaneously hypertensive rats. Delivery of Ang1-9 reduced cardiac fibrosis and improved endothelial function compared to control animals. These findings have implications for our understanding of RAS function.
|Item Type:||Thesis (PhD)|
|Keywords:||Renin-angiotensin system, hypertrophy, Angiotensin 1-9|
|Subjects:||R Medicine > R Medicine (General)|
|Colleges/Schools:||College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences|
|Supervisor's Name:||Nicklin, Dr. Stuart A.|
|Date of Award:||2010|
|Embargo Date:||7 June 2013|
|Depositing User:||Miss Monica Flores-Munoz|
|Copyright:||Copyright of this thesis is held by the author.|
|Date Deposited:||09 Jun 2010|
|Last Modified:||10 Dec 2012 13:48|
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