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Characterisation of response to antiepileptic drugs

Bamagous, Ghazi Ahmed (2010) Characterisation of response to antiepileptic drugs. PhD thesis, University of Glasgow.

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Abstract

This study aimed to construct a database of 1500 newly diagnosed patients with epilepsy referred to the epilepsy unit at the Western Infirmary in Glasgow between 1982 and 2005. These patients commenced their first ever epilepsy treatment at the unit. The database included demographic, clinical and investigational information together with a detailed account of every drug regimen applied starting from the first AED prescribed until the last follow up appointment. Using this database, I was able to identify the efficacy and tolerability of different AEDs in relation to various demographic, clinical and pharmacological characteristics. This analysis provides a better understanding of the natural history of treated epilepsy, an informational aid for the future prescription choice of drug and/or drug combination according to different patient characteristics and facilitates the study of patients with intractable seizures from a pharmacological point of view.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: epilepsy, antiepileptic drugs, response, outcome,
Subjects: R Medicine > RM Therapeutics. Pharmacology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Brodie, Prof. Martin
Date of Award: 2010
Depositing User: Dr. Ghazi Bamagous
Unique ID: glathesis:2010-2257
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 11 Nov 2010
Last Modified: 10 Dec 2012 13:53
URI: http://theses.gla.ac.uk/id/eprint/2257

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