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A study of omega-3 fatty acid therapy in patients with nephrotic syndrome

Siddiqui, Samira (2008) A study of omega-3 fatty acid therapy in patients with nephrotic syndrome. MD thesis, University of Glasgow.

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Abstract

Patients with nephrotic range proteinuria have a higher risk of cardiovascular disease through qualitative and quantative changes in lipids and lipoproteins. The aim of this study was to examine the effect of omega-3 fatty acids derived from fish oil in this population. Treatment with omega-3 fatty acids in these patients was well tolerated and had a number of beneficial effects. They reduced small dense LDL concentration, remnant lipoproteins, VLDL and triglyceride level. Postprandial lipaemia was improved with an improvement in chylomicron clearance. However, we found that treatment increased LDL-C and although there was a redistribution to protective HDL2 rather than HDL3, HDL-C was not significantly increased. Furthermore, there was no improvement in endothelial function or inflammatory markers. Thus, we do not recommend treatment with omega-3 fatty acids alone for dyslipidaemia in this population of patients. The combination of omega-3 fatty acids with a statin merits further work.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: omega-3 fatty acids, nephrotic syndrome, proteinuria, lipids, lipoproteins, postprandial lipaemia, chylomicrons, cholesterol, HDL, VLDL, LDL, small dense LDL, endothelial function, renal, dyslipidaemia.
Subjects: R Medicine > RC Internal medicine
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Caslake, Professor Muriel
Date of Award: 2008
Depositing User: Dr Samira Siddiqui
Unique ID: glathesis:2008-244
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 20 Aug 2008
Last Modified: 10 Dec 2012 13:17
URI: http://theses.gla.ac.uk/id/eprint/244

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