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Asymmetric synthesis of homoallylic alcohols and their applications

Barlog, Maciej L. (2011) Asymmetric synthesis of homoallylic alcohols and their applications. PhD thesis, University of Glasgow.

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Abstract

Herein it is presented a further development of the well-established catalytic asymmetric allylation of aldehydes leading to enantiopure homoallylic alcohols Stereogenic centre(s) served as the foundation for synthesis of a variety of other advanced intermediates and building blocks with multiple chiral centres - New approaches to homoallylic alcohols were dementrated with excellent control of chiral centers - Biologically relevant carbohydrate analogues were synthesised in four possible configurations using singlet oxygen raction as the key step - δ-hydroxy-β-amino acids were synthetised diastereoselectively using Pd catalysis as the key step. - A novel approach to synthesis of isoxazolidines and pyrazolidines was demonstrated

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Asymmetric synthesis, allylation, Palladium catalysed reactions, Carbonylation, beta amino acids, isoxazolidines.
Subjects: Q Science > QD Chemistry
Colleges/Schools: College of Science and Engineering > School of Chemistry
Supervisor's Name: Kočovský, Professor Pavel and Malkov, Professor Andrei V.
Date of Award: 2011
Embargo Date: 30 August 2014
Depositing User: Mr Maciej Barlog
Unique ID: glathesis:2011-2815
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 05 Sep 2011
Last Modified: 10 Dec 2012 14:00
URI: http://theses.gla.ac.uk/id/eprint/2815

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