Barlog, Maciej L.
Asymmetric synthesis of homoallylic alcohols and their applications.
PhD thesis, University of Glasgow.
Full text available as:
Herein it is presented a further development of the well-established catalytic asymmetric allylation of aldehydes leading to enantiopure homoallylic alcohols
Stereogenic centre(s) served as the foundation for synthesis of a variety of other advanced intermediates and building blocks with multiple chiral centres
- New approaches to homoallylic alcohols were dementrated with excellent control of chiral centers
- Biologically relevant carbohydrate analogues were synthesised in four possible configurations using singlet oxygen raction as the key step
- δ-hydroxy-β-amino acids were synthetised diastereoselectively using Pd catalysis as the key step.
- A novel approach to synthesis of isoxazolidines and pyrazolidines was demonstrated
Actions (login required)