Use of thrombolytic therapy beyond current recommendations for acute ischaemic stroke

Mishra, Nishant Kumar (2012) Use of thrombolytic therapy beyond current recommendations for acute ischaemic stroke. PhD thesis, University of Glasgow.

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Abstract

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trolled comparison of outcomes, I show better outcomes amongst all patients (P <
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t all patients (P < 0.0001; OR, 1.39; 95% CI, 1.26 to 1.54), young patients (P <
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 (odds ratio 1.6, 95% confidence interval 1.5 to 1.7; Cochran-Mantel-Haenszel P<
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on occurs independently amongst patients aged ≤80 (0R 1.6, 95%CI1.5 to 1.7; P<
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 to 1.7; P<0.001; n=25,789) and in those aged >80 (OR 1.4, 95% CI 1.3 to 1.6; P<
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rombolysed patients versus nonthrombolysed comparators amongst non-diabetic (P <
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hrombolysed versus nonthrombolysed patients who have not had a prior stroke (P <
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us and previous stroke (OR 1.23 [95% CI 0.996-1.52], P=0.05, N=1136), all CMH p<
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ring neither diabetes mellitus nor previous stroke: OR=1.53(95%CI 1.42-1.63), p<
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e of alteplase with improved outcomes for baseline NIHSS levels from 5 to 24 (p<
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Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Large portions of chapters 3 to 8 and some portions of chapter 1,2 and 9 have already been published in various journals like Stroke,Neurology,British Medical Journal and Diabetes Care.
Keywords: stroke,ischaemic,thrombolysis,EMEA,license,european, guidelines,mismatch, elderly,diabetes,prior stroke, mild stroke,severe stroke,SITS,VISTA
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Lees, Prof. Kennedy
Date of Award: 2012
Depositing User: Dr Nishant Mishra
Unique ID: glathesis:2012-3083
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 12 Jan 2012
Last Modified: 10 Dec 2012 14:03
URI: http://theses.gla.ac.uk/id/eprint/3083

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