The effect of the thiazolidinedione troglitazone and association of leptin on body composition in non-insulin dependent diabetes mellitus

Kelly, Irene Elizabeth (1998) The effect of the thiazolidinedione troglitazone and association of leptin on body composition in non-insulin dependent diabetes mellitus. MSc(R) thesis, University of Glasgow.

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Printed Thesis Information: https://eleanor.lib.gla.ac.uk/record=b1711732

Abstract

The present study examined the effect of the thiazolidione troglitazone and the influence of serum leptin on body composition in patients with non-insulin dependent diabetes mellitus. The study was designed as a double blind, randomised, placebo-controlled, parallel group trial, where subjects were allocated to receive either troglitazone or matching placebo. Sixteen males and seven females were recruited from the Diabetes Centre at Glasgow Royal Infirmary. All subjects were treated by diet alone or diet and sulphonylureas and had a fasting glucose between 8 and 16mmol/l. The commonly used anthropometric measurements as well as a standard underwater weighing method were employed to determine percentage body fat. A novel magnetic resonance imaging technique was used to calculate the volume of total abdominal and intra-abdominal fat. Serum leptin was analysed using a radioimmunoassay kit. The results of the study indicate that troglitazone had no significant effect on body weight of total body fat. However troglitazone did significantly reduce intra-abdominal fat. Analysis of leptin with measures of adiposity showed that leptin correlated significantly with body fat by underwater weighing and body mass index, but correlated weakly with intra-abdominal fat. These results suggest that subcutaneous adipose tissue (which is the main site of body fat) rather than intra-abdominal fat, is associated with leptin in overweight subjects with NIDDM. From the present study it is possible to suggest that: 1. Troglitazone significantly reduces intra-abdominal fat as measured by magnetic resonance imaging, but total body fat does not change significantly. 2. Troglitazone may preferentially increase insulin sensitivity and lipogenesis in tissues other than intra-abdominal fat, and the results would still be in keeping with minor (non significant) increases in other sites of adipose tissue. 3. A single magnetic resonance imaging scan of the intra-abdominal fat area at the intervertebral disc between L2 and L3 vertebrae offers a cheaper, faster and safer method, with high prediction of total-abdominal fat volumes. 4. Subcutaneous adipose tissue (the major body fat depot) rather than intra-abdominal fat, is associated with leptin in overweight diabetic subjects.

Item Type: Thesis (MSc(R))
Colleges/Schools: College of Medical Veterinary and Life Sciences
Supervisor's Name: Lean, Prof. Michael E.J.
Date of Award: 1998
Depositing User: Mrs Monika Milewska-Fiertek
Unique ID: glathesis:1998-38927
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 23 Nov 2018 08:12
Last Modified: 23 Nov 2018 08:12
URI: http://theses.gla.ac.uk/id/eprint/38927
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