Chromatin modification contributes to senescence associated proliferation arrest

Nelson, David Martin (2012) Chromatin modification contributes to senescence associated proliferation arrest. PhD thesis, University of Glasgow.

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Abstract

Senescence is a state of permanent proliferation arrest that normal cells undergo in response to shortened telomeres, oncogenic activation and other sources of cellular stress, thus restricting the replicative capacity of impaired or damaged cells. As such, senescence provides a potent mechanism of tumor suppression, but has also been implicated in organismal aging. Senescence is accompanied by profound chromatin remodeling, which reinforces several important features of the senescence program. Consequently, there is considerable interest in elucidating precisely how chromatin structure influences senescence. In the present work, I set out to investigate the role of the H4K20me3 histone modification in senescence, as the mark has been implicated in aging and is commonly lost in human cancers.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Senescence, chromatin, histone modification
Subjects: Q Science > Q Science (General)
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences > Beatson Institute of Cancer Research
Supervisor's Name: Adams, Prof. Peter
Date of Award: 2012
Depositing User: David Nelson
Unique ID: glathesis:2012-4220
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 24 May 2013 13:37
Last Modified: 18 Mar 2019 16:33
URI: http://theses.gla.ac.uk/id/eprint/4220

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