The measurement of choroidal blood flow using krypton-85

Strang, R (1975) The measurement of choroidal blood flow using krypton-85. PhD thesis, University of Glasgow.

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Abstract

Chapter 1 contains a brief description of the anatomy of the eye followed by a review of the methods used previously to measure ocular blood flow. The theory of the Inert gas clearance method for measuring blood flow in homogeneously perfused tissues is discussed, in Chapter 2. A series of experiments designed to measure control values of choroidal blood flow in rabbits using krypton-85 is described in Chapter 5. The clearance of krypton from rabbit ocular tissue is complex. An explanation of the complex nature of the clearance curve was obtained by studying the diffusion of krypton in ocular tissue. Initially a diffusion model whose structure was based on the anatomy of the rabbit eye was developed (Chapter 4). Predicted clearance curves, obtained from this model, indicated that the half life of the initial exponential decline of the clearance curve was a measure of choroidal blood flow and that the subsequent decline in radioactivity was dependent on the diffusion of krypton in ocular tissue, A model based on the anatomy of the baboon eye was also developed. In Chapter 6 the results of measurements of the linear absorption coefficient, solubilities and diffusion coefficients of krypton in the different ocular tissues are presented. These are necessary for the numerical evaluation of the model. In Chapter 7 method has been applied to examine the effect of increased arterial carbon dioxide tension on the choroidal blood flow in rabbits and baboons. The response of the choroidal blood flow in rabbits was variable. In the baboon there was a 3.5% increase in choroidal blood flew per mmHg rise in PaCO2. Chapter 8 is a general discussion of the work presented in this thesis and its value.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: F C Gillespie
Keywords: Ophthalmology, Morphology, Medical imaging
Date of Award: 1975
Depositing User: Enlighten Team
Unique ID: glathesis:1975-72329
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 24 May 2019 15:12
Last Modified: 24 May 2019 15:12
URI: http://theses.gla.ac.uk/id/eprint/72329

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