The intestinal mast cell in normal and parasitised rats

Miller, Hugh Robert Peel (1970) The intestinal mast cell in normal and parasitised rats. PhD thesis, University of Glasgow.

Abstract

Parasitic infections in man and animals continue to be the cause of severe social and economic problems on several continents; even in countries where highly efficient methods of agriculture have been developed, parasitism remains a source of grant financial loss to the farming community. Measures to combat infection include treatment with anthelminthics, improvement of hygiene, elimination of vectors and intermediate hosts as well as efficient husbandry. But these methods are often costly and not always practicable and in many instances a different approach is required. A major development in the prevention of parasitic infections was the introduction of vaccination techniques employing living irradicated larvae (Jarrett, Jennings, McIntyre, Mulligan and Urquhart, 1960; Urquhart, Jarrett and Mulligan 1962). But, as yet, many of the fundamental aspects of the immunity conferred by such techniques remain poorly understood. This has led to a renewed interest in the immune mechanisms involved in the expulsion of parasites from the host. It is essential to have an experimental system for exploratory studies which allows a detailed analysis of many of the factors involved. Large domestic animals are unsuitable because of the time and expense involved in quantitative experiments Nippostrongylus brasiliensis in the rat offers and excellent model system as it is easily quantitated, produces a good immunity and the life cycle is on a reasonable time scale. This thesis is a study of the role of the most cell and the mediators released by it in the immune response of the rate to this parasite.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: W FH Jarrett
• Keywords: Parasitology
• Date of Award: 1970
• Depositing User: Enlighten Team
• Unique ID: glathesis:1970-73900
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jun 2019 08:56
• Last Modified: 14 Jun 2019 08:56
• URI: https://theses.gla.ac.uk/id/eprint/73900