Studies Into the MAP Kinase Pathway of Cells Transformed by the FBR Murine Sarcoma Virus and Their Revertants

Katsanakis, Konstantinos D (1998) Studies Into the MAP Kinase Pathway of Cells Transformed by the FBR Murine Sarcoma Virus and Their Revertants. PhD thesis, University of Glasgow.

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Abstract

Neoplastic transformation by the FBR fos oncogene is associated with aspects of the transformed phenotype such as morphological alterations, anchorage-independent growth and metastasis. The products of the FBR and FBJ fos oncogenes are members of the transcription factor AP-1, which operates downstream of the growth factor - ras - MAP Kinase pathway in mammalian cells. The constituents of this pathway, such as the protein kinases Raf-1 and MEK- 1 are necessary for normal and oncogenic cell growth.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: Brad Ozanne
Keywords: Medicine, Cellular biology
Date of Award: 1998
Depositing User: Enlighten Team
Unique ID: glathesis:1998-74516
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 13 Nov 2019 15:58
Last Modified: 13 Nov 2019 15:58
URI: https://theses.gla.ac.uk/id/eprint/74516

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