Stochastic Modelling of Tumorigenesis in p53 Deficient Transgenic Mice

Mao, Jian-Hua (1997) Stochastic Modelling of Tumorigenesis in p53 Deficient Transgenic Mice. PhD thesis, University of Glasgow.

Abstract

The aim of this project was to develop the stochastic models of tumorigenesis to investigate the implications of experimental data on tumour induction in wild type and p53 deficient mice for tumorigenesis mechanisms. These studies have focused on the development of stochastic process models for p53 mediated spontaneous and radiation- induced tumorigenesis in mice, in which up to 3 stages are assumed to be required for malignant transformation. The stages are conceived as the inactivation of one and both p53 alleles with a third, genetically unspecified stage which may be composite. The model has been used to explore the influence of mutation rate, stage number, and the number of stem cells at risk on the kinetics of spontaneous appearance of tumours and tumour multiplicity. As expected, tumours tended to occur earlier and the more tumours per mouse tend to be acquired with lesser stage number, higher mutation rate and higher stem cell number.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Tom Wheldon
• Keywords: Molecular biology, Oncology
• Date of Award: 1997
• Depositing User: Enlighten Team
• Unique ID: glathesis:1997-74576
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 13 Nov 2019 15:58
• Last Modified: 13 Nov 2019 15:58
• URI: https://theses.gla.ac.uk/id/eprint/74576