Structural Studies on the Herpes Simplex Virus Type 1 Genome During Latency in Tissue Culture Cells

Jamieson, Douglas Ramsay Stuart (1993) Structural Studies on the Herpes Simplex Virus Type 1 Genome During Latency in Tissue Culture Cells. PhD thesis, University of Glasgow.

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Abstract

Herpes simplex virus (HSV) has the pathogenic property of establishing latency during primary infection of man. Following the primary infection at a peripheral site, virions travel via the axons to the neuronal cell bodies in sensory or autonomic ganglia where latency is established and maintained. The virus can be reactivated, return down the axon to the periphery, replicate, be shed and transmitted to other individuals. This gives rise to clinically important recurrent disease, namely herpes labialis, keratitis, uveitis and genitalis. Reactivation is of increasing importance in immunocompromised individuals. Encephalitis, presumed to be due to reactivation of latent virus from the trigeminal ganglion, is the most serious manifestation with a mortality rate of about 50% if untreated and considerable morbidity in half of the survivors.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: P G E Kennedy
Keywords: Virology
Date of Award: 1993
Depositing User: Enlighten Team
Unique ID: glathesis:1993-74580
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 27 Sep 2019 17:41
Last Modified: 27 Sep 2019 17:41
URI: http://theses.gla.ac.uk/id/eprint/74580

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