An Investigation of Heredity in the Aetiology and Pathogenesis of Cleft Palate and of Cleft Lip and Palate

Mossey, Peter Anthony (1994) An Investigation of Heredity in the Aetiology and Pathogenesis of Cleft Palate and of Cleft Lip and Palate. PhD thesis, University of Glasgow.

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Abstract

Cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) are caused by primary defects in the fusion of craniofacial processes that form the primary and secondary palate respectively. CL(P) and CP are considered to be separate diagnostic entities and for both multifactorial inheritance has been proposed, although the precise roles played by genes, environment and chance are unclear; and in particular the nature and number of genes involved is not known. The aim of this study was to try to identify parental characteristics (genotypic or phenotypic) which were associated with an increased risk of having a child with CL(P) or CP. The combination of phenotypic and genotypic data can improve the ability to predict parental predisposition towards CP or CL(P) beyond the predictive ability of either cephalometric or genetic data in isolation. The lack of correlation between these genotypes and the cephalometric parameters would suggest that other genetic loci are involved in the predisposition to CL(P) and CP and further analysis of other candidate genes using this approach would merit consideration. (Abstract shortened by ProQuest.).

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: Reynir Arngrimsson
Keywords: Dentistry
Date of Award: 1994
Depositing User: Enlighten Team
Unique ID: glathesis:1994-74912
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 27 Sep 2019 15:13
Last Modified: 27 Sep 2019 15:13
URI: http://theses.gla.ac.uk/id/eprint/74912

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