Gastric Cancer: Natural History and Treatment

Cunningham, David (1987) Gastric Cancer: Natural History and Treatment. MD thesis, University of Glasgow.

Full text available as:
[img]
Preview
PDF
Download (5MB) | Preview

Abstract

In this thesis we have defined the group of patients with gastric cancer who do well after surgical resection. Patients in whom the tumour has penetrated the serosa do badly, even if they have an apparently curative resection. For this group of patients, surgery alone is insufficient treatment and some form of adjuvant therapy is clearly required. The best candidate at the moment is chemotherapy but so far the results of adjuvant chemotherapy have been disappointing. Another possible approach involves the use of intraperitoneal chemotherapy given in the adjuvant setting because as outlined in Chapter Two, tumours which have penetrated the serosa are often associated with free cancer cells in the peritoneum. Cisplatin, one of the most active drugs in gastric cancer, has been given by the intraperitoneal route to treat ovarian cancer but not gastric cancer. This route of administration effectively delivers 15 times the equivalent intravenous dose to the peritoneum and because it is absorbed via the peritoneum it also has a systemic effect (216). This systemic effect would be necessary to eradicate micrometastatic disease outwith the peritoneum.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: Medicine, Oncology
Date of Award: 1987
Depositing User: Enlighten Team
Unique ID: glathesis:1987-76659
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 19 Nov 2019 13:57
Last Modified: 19 Nov 2019 13:57
URI: http://theses.gla.ac.uk/id/eprint/76659

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year