Alteration of the Small Cell Lung Cancer Phenotype and Its Effect on Chemosensitivity

Murray, Alison M. B (1989) Alteration of the Small Cell Lung Cancer Phenotype and Its Effect on Chemosensitivity. PhD thesis, University of Glasgow.

Abstract

Small cell lung cancer (SCLC) accounts for approximately 25% of all lung cancers. It is distinguished from other lung cancers by the presence of neurosecretory granules, frequent peptide secretion, high levels of L-DOPA decarboxylase (DDC), creatine kinase BB isoenzyme (CKBB) ,neurone specific enolase (NSE) and bombesin-like immunoreactivity (BLI). It is a particularly aggressive neoplasm which has the potential for early metastatic dissemination, and by the time of diagnosis metastatic spread is often extensive. Consequently, surgical removal of the tumour is in most cases unlikely to result in a cure from the disease and chemotherapy is the most important treatment modality for SCLC. The eventual goal in the treatment of SCLC is to develop effective systemic therapy that will produce high response rates and a high percentage of long term disease-free survivors (cures).

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Oncology
• Date of Award: 1989
• Depositing User: Enlighten Team
• Unique ID: glathesis:1989-76844
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:32
• Last Modified: 14 Jan 2020 09:32
• URI: https://theses.gla.ac.uk/id/eprint/76844