Transcriptional Regulation of the Interferon Genes

MacDonald, Nicholas J (1990) Transcriptional Regulation of the Interferon Genes. PhD thesis, University of Glasgow.

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Abstract

Interferons (IFNs) are a class of regulatory cytokines capable of inducing a non-specific antiviral activity in target cells. Under normal conditions the synthesis of IFN is not usually detectable, but following exposure of cells to inducers such as virus or double stranded RNA, IFN is produced in large amounts. Expression of the IFN genes is tissue specific and comes about by the activation of transcription. Cis-acting virus responsive elements (VREs) responsible for transcriptional activation have been identified within the 5'-flanking sequences of the human IFN-alpha1 and -beta genes and show considerable sequence similarity.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Genetics, Molecular biology
Date of Award: 1990
Depositing User: Enlighten Team
Unique ID: glathesis:1990-76974
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jan 2020 09:25
Last Modified: 14 Jan 2020 09:25
URI: http://theses.gla.ac.uk/id/eprint/76974

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