The Regulation of Adenylate Cyclase in Adipose Tissue From the Streptozotocin Diabetic Rat, the Obese Zucker Rat and the Diabetic Mouse

Strassheim, Derek (1991) The Regulation of Adenylate Cyclase in Adipose Tissue From the Streptozotocin Diabetic Rat, the Obese Zucker Rat and the Diabetic Mouse. PhD thesis, University of Glasgow.

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Abstract

In this study I have investigated alterations in the regulation and hormonal responsiveness of adipocyte adenylate cyclase occurring in animal models showing insulin-resistance. Three models have been investigated, the streptozotocin diabetic rat, which approximates as a model of juvenile onset diabetes in humans, genetically obese Zucker fatty rat, approximating a model of human obesity and the genetically obese diabetic mouse, which also approximates to a model of human obesity. My reason for undertaking such a study was because therapeutic benefits may come from a greater understanding of alterations in signal transduction systems of hormones controlling metabolism in insulin-resistant pathological states. These are seen in diabetes and in obesity where profound alterations in metabolism have been noted. An important underlying facet in determining these alterations in metabolism may be that defects have occurred in signal transduction systems of various hormones which regulate metabolic events. Any such changes occuring in signal transduction systems associated with the liver, skeletal muscle and adipose tissue are likely to give rise to serious metabolic disturbances.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Biochemistry, Physiology
Date of Award: 1991
Depositing User: Enlighten Team
Unique ID: glathesis:1991-77025
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jan 2020 09:23
Last Modified: 14 Jan 2020 09:23
URI: http://theses.gla.ac.uk/id/eprint/77025

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