Monocyte C1-Inhibitor Synthesis

Jones, Linda Margaret (1987) Monocyte C1-Inhibitor Synthesis. PhD thesis, University of Glasgow.

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Abstract

C1-inhibitor is the major control protein of the classical pathway of complement. In man, its hereditary deficiency results in the clinical condition of hereditary angio-oedema (HAE). The disease is characterised by recurrent episodes of acute, circumscribed, non-inflammatory oedema involving the subcutaneous tissues and mucous membranes. Acquired C1-inhibitor deficiency can also occur without any previous family history, at a later stage in life and is usually associated with a lymphoproliferative disorder or paraproteinaemia. C1-inhibitor deficiency is treated by the administration of anabolic steroids, such as danazol or stanozolol, which are known to increase hepatic synthesis of C1-inhibitor, resulting in an increase in plasma C1-inhibitor.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Molecular biology
Date of Award: 1987
Depositing User: Enlighten Team
Unique ID: glathesis:1987-77530
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jan 2020 11:53
Last Modified: 14 Jan 2020 11:53
URI: http://theses.gla.ac.uk/id/eprint/77530

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