Describing size and shape changes in the human mandible from 9 to 15 years - comparison of elliptical Fourier function and Procrustes methods

Easton, Valerie J. (2000) Describing size and shape changes in the human mandible from 9 to 15 years - comparison of elliptical Fourier function and Procrustes methods. PhD thesis, University of Glasgow.

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Printed Thesis Information: http://eleanor.lib.gla.ac.uk/record=b1949549

Abstract

In the past, there have been many attempts to capture the size and shape information inherent in complex irregular objects by numerical representation. There is much to be gained in a biological sense by numerical description of complex forms, like the craniofacial complex, in the field of dentistry. This thesis aims to review, utilise and build on past research methods in an attempt to describe the size and shape changes of a sample of human mandibles from the age of 9 through to 15 years. Specifically, two methods are considered and contrasted, the elliptical Fourier function and Procrustes analysis (including Bookstein co-ordinates). In chapter 1 the background and motivation for such an investigation is introduced, describing the need for a mathematical description of complex irregular forms with an emphasis on the importance of such models in dentistry with particular reference to the way in which the human mandible grows over time. The methodological and clinical issues of the problem are outlined, including a summary of up to date methods that have been used to capture size and shape information of a growing complex morphological form and an overview of the way in which the mandible grows. Both the so-called landmark dependent and landmark independent (boundary outline) methods are summarised. Whilst all the methods considered are not without constraint in describing the size and shape of complex forms, all have been seen in the past to be beneficial in some way in that they all model 'form' in one way or another at the very least. Chapter 2 then considers in more depth, what is fast becoming a much-promoted method of describing irregular forms, the elliptical Fourier function (EFF). The use of conventional Fourier methods, as well as the newer EFF method in describing size and shape changes is reviewed. A suite of programs that have been specially written to apply the EFF method in the description of complex irregular forms is introduced and an overview of the specific routines available in the package is given. The data sample available for investigation, which consists of a series of lateral head cephalograms (x-rays) from the BC Leighton Growth Study, is described in Chapter 3. The way in which a subset is selected following certain inclusion and exclusion criteria from the available x-rays is outlined. The way in which the mandibular data is then prepared for subsequent use in the EFF suite of programs, as well as with the method of Procrustes (and Bookstein co-ordinates) is also described in some detail. In Chapter 4, an error study is undertaken to investigate the reproducibility of the tracings of the sample of mandibular outlines prepared in the previous chapter. Both 11 within- and between-rater studies are looked at. The EFF method is then applied to the sample of tracings collected by one observer to explore any changes in size and shape that may occur as the mandible grows, concentrating on ages 9, 11, 13 and 15 years. As well as producing some very informative plots of the observed and predicted mandibular outlines, and centroid to boundary outline distances, the usefulness of the harmonic information available from the EFF procedure for numerically describing size and shape changes of a complex irregular form is investigated. Whether or not there are differences between males and females in the data sample, in terms of the size and / or shape of the mandible is also explored. Finally, the method of Procrustes analysis (and Bookstein co-ordinates) is described in more depth in Chapter 5. This particular method is also applied to the same sample of mandibular outlines in order to investigate its usefulness in describing size and shape changes of the human mandible from age 9 to 15 years. Shape variability within samples is also explored by way of principal components analysis. In addition, the method of thin plate splines (TPS) is applied in order to examine shape change between males and females. Similar observations were made about mandibular growth in the sample investigated using both the EFF and Procrustes (along with Bookstein co-ordinates) procedures. Overall, the mandible was observed to be 'growing' between ages 9 and 15 i.e. changing in both size and shape over a period of time. There was no difference in terms of the size and shape of the bone between males and females in the sample, for each age. Further, using Procrustes analysis (and Bookstein co-ordinates) there did not appear to be any association between the size and shape of the mandibular outlines in either the male or female samples, for all ages. In addition, investigating shape variability using Procrustes methods by way of principal components analysis, resulted in broadly similar patterns for males and females, as well as combined samples, and different age groups. It is concluded in Chapter 6 that the methods of elliptical Fourier function and Procrustes (and Bookstein co-ordinates) both provide a very useful framework in which to describe the size and shape of complex irregular forms like the mandible. Although both methods have their advantages and disadvantages, Procrustes (including the very useful method using Bookstein co-ordinates) is preferred for statistical purposes.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Subjects: H Social Sciences > HA Statistics
Colleges/Schools: College of Science and Engineering > School of Mathematics and Statistics > Statistics
Funder's Name: UNSPECIFIED
Supervisor's Name: McColl, Professor John
Date of Award: 2000
Depositing User: Adam Swann
Unique ID: glathesis:2000-8392
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 13 Sep 2017 15:14
Last Modified: 13 Sep 2017 15:14
URI: http://theses.gla.ac.uk/id/eprint/8392

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