Post-polymerisation functionalisation of polyethers by Olefin cross metathesis

Morrison, Stephen (2017) Post-polymerisation functionalisation of polyethers by Olefin cross metathesis. PhD thesis, University of Glasgow.

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Printed Thesis Information: https://eleanor.lib.gla.ac.uk/record=b3285105

Abstract

Industrial uses of polyethers have expanded to medical applications, ranging from artificial tissues (i.e. implants, sutures and prosthetics), to the encapsulation of drugs; however post-polymerisation functionalisation methods are limited. Olefin cross metathesis (CM) is a powerful carbon-carbon bond forming reaction, and therefore could potentially conjugate polymers possessing pendent olefin handles. This could be of significant importance as the alkenes do not readily interfere with common polymerisation techniques such as anionic ring opening polymerisation (ROP), polyesterifications, or polyamidations.

This project describes the synthesis of novel biocompatible polyethers with diverse pendent olefins and their cross metathesis reaction with a range of partners. These various polymers are designed to probe the possibility of preventing the occurrence of self metathesis upon functionalisation using Hoveyda-Grubbs’ second-generation catalyst. One such polymer has been proven to be immune to the undesired self metathesis pathway allowing for retention of the low polymer dispersity (Ɖ = 1.15). We have shown that the cell signalling peptide RGD can be coupled efficiently to this polymer.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Polymer, cross metathesis, Olefin, polyether.
Subjects: Q Science > QD Chemistry
Colleges/Schools: College of Science and Engineering > School of Chemistry
Funder's Name: Engineering and Physical Sciences Research Council (EPSRC), Engineering and Physical Sciences Research Council (EPSRC), Engineering and Physical Sciences Research Council (EPSRC)
Supervisor's Name: Prunet, Dr. Joëlle and Liskamp, Prof. Robert
Date of Award: 2017
Depositing User: Mr Stephen Morrison
Unique ID: glathesis:2017-8435
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 28 Sep 2017 15:24
Last Modified: 02 Oct 2018 10:31
URI: http://theses.gla.ac.uk/id/eprint/8435

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