Investigation of the pseudokinase TRIB2: a double-edged sword in AML

Salomè, Mara (2017) Investigation of the pseudokinase TRIB2: a double-edged sword in AML. PhD thesis, University of Glasgow.

Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.

Abstract

TRIB2 belongs to the TRIBBLES family of serine/threonine pseudokinases (TRIB1, TRIB2 and TRIB3). TRIBBLES regulate proliferation, survival, differentiation, metabolism and stress responses, and their expression is frequently deregulated in cancer, including Acute myeloid leukaemia (AML). AML is a heterogeneous group of blood malignancies characterised by differentiation block and uncontrolled proliferation of myeloid precursor cells. Aberrant TRIB2 expression drives myeloid transformation through downregulation of the tumour suppressor CCAAT/enhancer-binding protein (C/EBPα). However, the mechanism of TRIB2 gene deregulation in cancer, and the role of TRIB2 in the oncogenic pathways of other AML oncogenes have not been fully investigated. Moreover, there is still limited information regarding the expression and function of TRIB2 and its family members, in the haemopoietic system, and how this is altered in different AML subtypes. This work aims to address these biological questions, by employing in silico, in vitro and in vivo experimental strategies.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Supported by funding from Friends of the Paul O'Gorman Leukaemia Research Centre.
Keywords: Trib2, Acute myeloid leukaemia, pseudokinase.
Subjects: Q Science > QH Natural history > QH301 Biology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences > Paul O'Gorman Leukemia Research Centre
Supervisor's Name: Keeshan, Dr. Karen
Date of Award: 2017
Embargo Date: 3 November 2019
Depositing User: Dr Mara Salomé
Unique ID: glathesis:2017-8572
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 03 Nov 2017 12:13
Last Modified: 11 Dec 2017 10:35
URI: http://theses.gla.ac.uk/id/eprint/8572
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