Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins

Spandidos, Nikiforos (2010) Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins. PhD thesis, University of Glasgow.

Abstract

RNA polymerase III (pol III) is responsible for transcribing a set of genes that are involved in protein synthesis, including transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Pol III transcription levels are increased in many cancers, as increased protein synthesis is required for tumour growth. Furthermore, it has been shown that a number of oncoproteins and tumour suppressor proteins interact directly with the pol III machinery. The work presented in this thesis aimed to investigate whether the inhibitor of differentiation (ID) and E47 proteins regulate pol III transcription, as well as the mechanisms behind these processes.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: ID1, ID2, ID3, E47, Pol III
• Subjects: Q Science > Q Science (General)
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Supervisor's Name: White, Prof. Robert J.
• Date of Award: 2010
• Depositing User: Mr Nikiforos/na Spandidos
• Unique ID: glathesis:2010-1723
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 16 Apr 2010
• Last Modified: 26 Apr 2013 08:51
• URI: https://theses.gla.ac.uk/id/eprint/1723