Magnetic resonance imaging of the right ventricle in human pulmonary hypertension

Blyth, Kevin G (2008) Magnetic resonance imaging of the right ventricle in human pulmonary hypertension. MD thesis, University of Glasgow.

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Pulmonary Hypertension (PH) is a rare but devastating illness which results in progressive right ventricular (RV) failure and early death. RV function determines
survival in all patients with PH but it is difficult to measure accurately using existing clinical techniques. The choice and design of the experiments in this thesis was
driven by a desire to improve our understanding of the reasons for right, and left,ventricular dysfunction in this context. Cardiovascular magnetic resonance (CMR)imaging was utilized throughout as it allows the non-invasive, direct and accurate study of both ventricles; at rest and during stress. In Chapter 3, CMR imaging was used to identify an NT-proBNP threshold (1685 ng/l, sensitivity 100%, specificity 94%) for the non-invasive detection of RV systolic dysfunction in patients with PH. In Chapter 4, contrast-enhanced-CMR was utilized for the first time in PH patients and revealed previously unidentified areas of myocardial fibrosis within the RV insertion points and interventricular septum. The extent of these areas correlated inversely with RV ejection fraction (r = -0.762, p < 0.001). Septal contrast enhancement was particularly associated with bowing of the interventricular septum.
Finally, in Chapter 5, dobutamine stress-CMR was used to determine the individual reasons for right and left ventricular stroke volume impairment during exercise in PH
patients. ∆ RV stroke volume appeared limited by diminished contractile reserve as ∆ RVEF was lower in PH patients (27%) compared to controls (38%) and ∆ RVEF correlated with ∆ RV stroke volume (r = 0.94, p < 0.001). ∆ LV stroke volume
appeared limited by impaired filling, probably due to reduced LV preload as RV stroke volume and LV end-diastolic volume remained closely related at rest (r = 0.821, p < 0.001) and stress (r = 0.693, p = 0.003).

Item Type: Thesis (MD)
Qualification Level: Doctoral
Keywords: Pulmonary Hypertension, Right Ventricle, Magnetic Resonance Imaging, NT-proBNP, delayed contrast enhancement, gadolinium, Dobutamine-stress
Subjects: R Medicine > R Medicine (General)
Q Science > QP Physiology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Supervisor's Name: Peacock, Professor Andrew
Date of Award: 2008
Depositing User: Dr Kevin Blyth
Unique ID: glathesis:2008-248
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 19 Aug 2008
Last Modified: 10 Dec 2012 13:17

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