An investigation into the relationships between host and tumour related factors and their influence on survival in patients with colorectal cancer

Roxburgh, Campbell S.D. (2011) An investigation into the relationships between host and tumour related factors and their influence on survival in patients with colorectal cancer. PhD thesis, University of Glasgow.

Abstract

Colorectal cancer is the second commonest cause of cancer death in the western world. In addition to tumour factors such as depth of invasion, lymph node involvement and venous invasion it is increasingly recognised that host factors, are important determinants of survival. In particular the host local and systemic inflammatory responses are stage independent predictors of survival in operable disease. The present thesis further examines the prognostic importance of host and tumour factors in colorectal cancer, specifically:
1. An examination of the prognostic importance of venous invasion (detected using elastica stains) in colorectal cancer.
2. Detailed analysis of the determinants (including age, comorbidity and deprivation) of the systemic inflammatory response and their relationship with survival.
3. The application and validation of a prognostic score providing a measure of the local inflammatory response in colorectal cancer.
4. Detailed analysis of the determinants (including all white cells, lymphocytes and macrophages) of the local inflammatory response and their relationship with survival.
5. The inter-relationships between the local and systemic inflammatory responses in colorectal cancer specifically: early stage disease (node negative) and in patients receiving adjuvant chemotherapy.
6. Mediators (including immunological parameters and vitamin antioxidants) of the local and systemic inflammatory responses and their relationship with survival.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Colorectal cancer, surgery, survival, inflammation, systemic inflammatory response, local inflammatory response, tumour infiltrating lymphocytes, cytokines, vitamins, adjuvant chemotherapy, venous invasion, elastica staining.
• Subjects: R Medicine > RB Pathology; R Medicine > RD Surgery
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Supervisor's Name: McMillan, Prof. D.C.
• Date of Award: 2011
• Depositing User: Mr Campbell Roxburgh
• Unique ID: glathesis:2011-2763
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 05 Aug 2011
• Last Modified: 18 Jul 2014 12:59
• URI: https://theses.gla.ac.uk/id/eprint/2763