Asymmetric synthesis of homoallylic alcohols and their applications

Barlog, Maciej L. (2011) Asymmetric synthesis of homoallylic alcohols and their applications. PhD thesis, University of Glasgow.

Abstract

Herein it is presented a further development of the well-established catalytic asymmetric allylation of aldehydes leading to enantiopure homoallylic alcohols
Stereogenic centre(s) served as the foundation for synthesis of a variety of other advanced intermediates and building blocks with multiple chiral centres
- New approaches to homoallylic alcohols were dementrated with excellent control of chiral centers
- Biologically relevant carbohydrate analogues were synthesised in four possible configurations using singlet oxygen raction as the key step
- δ-hydroxy-β-amino acids were synthetised diastereoselectively using Pd catalysis as the key step.
- A novel approach to synthesis of isoxazolidines and pyrazolidines was demonstrated

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Asymmetric synthesis, allylation, Palladium catalysed reactions, Carbonylation, beta amino acids, isoxazolidines.
• Subjects: Q Science > QD Chemistry
• Colleges/Schools: College of Science and Engineering > School of Chemistry
• Supervisor's Name: Kočovský, Professor Pavel and Malkov, Professor Andrei V.
• Date of Award: 2011
• Depositing User: Mr Maciej Barlog
• Unique ID: glathesis:2011-2815
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 05 Sep 2011
• Last Modified: 15 Oct 2014 09:06
• URI: http://theses.gla.ac.uk/id/eprint/2815