Mining genome data for endogenous viral elements and interferon stimulated genes: insights into host virus co-evolution

Dennis, Tristan Philip Wesley (2018) Mining genome data for endogenous viral elements and interferon stimulated genes: insights into host virus co-evolution. PhD thesis, University of Glasgow.

Abstract

Paleovirology is the study of viruses over evolutionary timescales. Contemporary paleovirological analyses often rely on sequence data, derived from organism genome assemblies. These sequences are the germline inherited remnants of past viral infection, in the form of endogenous viral elements and the host immune genes that are evolving to combat viruses. Their study has found that viruses have exerted profound influences on host evolution, and highlighted the conflicts between viruses and host immunity. As genome sequencing technology cheapens, the accumulation of genome data increases, furthering the potential for paleovirological insights. However, data on ERVs, EVEs and antiviral gene evolution, are often not captured by automated annotation pipelines. As such, there is scope for investigations and tools that investigate the burgeoning bulk of genome data for virus and and antiviral gene sequence data in the search of paleovirological insight.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Virus, endogenous, evolution, palaeovirology, mouse, circovirus, ISG, antiviral gene.
• Subjects: Q Science > QH Natural history > QH426 Genetics; Q Science > QR Microbiology > QR355 Virology
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Supervisor's Name: Wilson, Dr. Sam and Gifford, Dr. Robert
• Date of Award: 2018
• Depositing User: Tristan Dennis
• Unique ID: glathesis:2018-30887
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 17 Oct 2018 14:50
• Last Modified: 13 Nov 2018 08:41
• URI: https://theses.gla.ac.uk/id/eprint/30887

Related URLs

• Article DOI
• Enlighten Publications Record
• Article DOI
• Enlighten Publications Record
• Article DOI
• Enlighten Publications Record