Regulation of gene expression in the basal ganglia

Simpson, Carol S. (1995) Regulation of gene expression in the basal ganglia. PhD thesis, University of Glasgow.

Abstract

Enkephalin gene expression is modulated by the dopaminergic system in the rat striatum. Intraperitoneal administration of the typical neuroleptic drugs haloperidol (1mg/kg) and fluphenazine (3mg/kg) significantly increase levels of proenkephalin mRNA in the caudal striatum compared to saline treated controls, although the atypical neuroleptic drug clozapine (3mg/kg) has no effect on the levels of proenkephalin mRNA in the rat. Methiothepin (10mg/kg), an antipsychotic with the ability to antagonise both serotonin and dopamine receptors, can also induce proenkephalin mRNA levels in rat striatum. This induction is observed twenty-four hours after the drugs are given.

Tachykinin gene expression is modulated by the dopaminergic system in the rat striatum. Intraperitoneal administration of the typical neuroleptic drugs haloperidol (1mg/kg) and fluphenazine (3mg/kg) significantly reduce the levels of preprotachykinin mRNA in the rat striatum, compared to saline treated controls. This effect is observed twenty-four hours after drug administration. The atypical neuroleptic drug clozapine (3mg/kg) and the antipsychotic methiothepin (10mg/kg) have no significant effect on the levels of preprotachykinin mRNA in the rat striatum.

Somatostatin gene expression in the rat striatum is significantly increased by low doses of the atypical neuroleptic drug clozapine (3mg/kg) and by the antipsychotic drug methiothepin (10mg/kg), after acute administration. Acute treatment with typical neuroleptics has no effect in the rat striatum.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Supported by funding from the Wellcome Trust.
• Colleges/Schools: College of Medical Veterinary and Life Sciences
• Supervisor's Name: Morris, Dr. Brian J.
• Date of Award: 1995
• Depositing User: Mrs Monika Milewska-Fiertek
• Unique ID: glathesis:1995-38912
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 08 Nov 2018 14:36
• Last Modified: 16 Jul 2021 14:04
• Thesis DOI: 10.5525/gla.thesis.38912
• URI: https://theses.gla.ac.uk/id/eprint/38912

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