Genetic control of development in the parasitic nematode Haemonchus contortus by microRNAs

Marks, Neil Derek (2016) Genetic control of development in the parasitic nematode Haemonchus contortus by microRNAs. PhD thesis, University of Glasgow.

Abstract

The parasitic nematode Haemonchus contortus has a major impact on the welfare and economic sustainability of small ruminant farming throughout the world. Increasing drug resistance requires the development of novel therapeutic agents. To further this process, we examined the fundamental biology of development in H. contortus, specifically, the potential role of microRNAs (miRNAs). miRNAs are short, non-coding RNA molecules that negatively regulate gene expression. In the free-living nematode Caenorhabditis elegans, miRNAs regulate a variety of genes including those involved in development. This thesis describes the expression patterns, potential targets and possible functions of miRNAs in H. contortus throughout development.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Subjects: Q Science > QR Microbiology; S Agriculture > SF Animal culture > SF600 Veterinary Medicine
• Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
• Supervisor's Name: Britton, Dr. Collette and Devany, Prof. Eileen
• Date of Award: 2016
• Depositing User: Dr Neil D Marks
• Unique ID: glathesis:2016-7021
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 30 Jun 2016 14:03
• Last Modified: 28 Jan 2019 10:05
• URI: https://theses.gla.ac.uk/id/eprint/7021