Ali, Zeeshan
(2004)
A study of murine vascular alpha1-adrenoceptors: A functional knockout approach.
PhD thesis, University of Glasgow.
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Abstract
Currently, traditional pharmacological techniques are being increasingly complimented by applying parallel transgenic approaches employing the use of functional knock-out, over-expressed and site-directed mutagenesis models of individual proteins in order to determine their functional role or distribution within cells and tissues. Recent advances have provided individual functional knockout models of the three alpha1- AR subtypes (alpha1A-KO, alpha1B-KO and alpha1D-KO). All three have been implicated as having a role in the maintenance of blood pressure, as a result of studies of the phenotypes of the individual KO models. However, of the three alpha1-ARs, only the alpha1D and alpha1B-AR have been reported to be involved in vasoconstriction of the mouse aorta. As such, the alpha1D-AR is reported to be the major adrenergic vasoconstrictor with a minor role for alpha1B- ARs. The data presented in this thesis is the result of a detailed pharmacological study, aided by the use of transgenic mice of the alpha1-ARs involved in the functional responses of the mouse aorta. (Abstract shortened by ProQuest.).
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