Immunopotentiation studies with Vibrio cholerae

Lauchlan, Carol Elizabeth (1978) Immunopotentiation studies with Vibrio cholerae. PhD thesis, University of Glasgow.

Full text available as:
Download (24MB) | Preview


The main shortcomings in the present cholera immunisation schemes are the incomplete protection afforded by currently available vaccines and the short duration of the immunity stimulated. This study (in laboratory animals) was undertaken to investigate possible alternatives to the current commercial vaccine which is a heat-killed, saline suspension of V. cholerae. The following were considered :- 1. Use of cholera toxoid as immunogen, either in preference to or in conjunction with heat-killed V. cholerae cells. Cholera toxin is known to be responsible for the pathogenesis of cholera and therefore toxoid-containing vaccines might provide an alternative to the whole cell vaccine. 2. Use of oral or combined i/m and oral immunisation schedules. Cholera vibrios and toxin are completely confined to the lumen of the intestine during infection; therefore it is important to stimulate a gut-associated antibody response. Oral immunisation may stimulate such a response, perhaps better than the s/c or i/m routes of immunisation currently employed. 3. Incorporation of vaccines into adjuvant mixtures. Protection against cholera has been associated with high serum antibody titres so that stimulation of the immune response to the protein enterotoxin by adjuvants was thought to be a worthwhile line of investigation. Wherever possible the practicality of using a vaccine in the field was considered. The main aim was to obtain an immunisation schedule which could be put into operation with minimal involvement of qualified personnel. For this reason the oral route of administration was strongly favoured.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: D ES Stewart-Tull
Keywords: Pharmacology, Immunology
Date of Award: 1978
Depositing User: Enlighten Team
Unique ID: glathesis:1978-72093
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 17 May 2019 13:02
Last Modified: 17 May 2019 13:02

Actions (login required)

View Item View Item


Downloads per month over past year