Monoamine-sensitive adenylate cyclase in the nervous system of the locust schistocerca gregaria

Kilpatrick, Andrew Thomas (1981) Monoamine-sensitive adenylate cyclase in the nervous system of the locust schistocerca gregaria. PhD thesis, University of Glasgow.

Abstract

The observation that dopamine, octopamine and serotonin represent the major monoamines present in insect nervous tissue has led to speculation about their role. For the monoamines to act as neurotransmitters, receptors should exist. Moreover, if chemical neurotransmission involves cyclic AMP as a "second messenger", then monoamine receptors linked to adenylate cyclase should also be present. The aim of this work was to determine whether locust cerebral ganglia possessed an adenylate cyclase that was affected by these monoamines present in Schistocerca gregaria nervous tissue and, if so, to see if the response was mediated by separate receptors. In addition, a comparison of the properties of the locust adenylate cyclase with those from other organisms was carried out. Cerebral ganglia of S. gregaria contain an adenylate cyclase-4 stimulated maximally, in the presence of 10.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: P FT Vaughan
• Keywords: Neurosciences
• Date of Award: 1981
• Depositing User: Enlighten Team
• Unique ID: glathesis:1981-72227
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 24 May 2019 15:12
• Last Modified: 24 May 2019 15:12
• URI: https://theses.gla.ac.uk/id/eprint/72227