Induced abnormal bone growth with particular reference to the growth plate

Duff, Stuart Roderick Iain (1979) Induced abnormal bone growth with particular reference to the growth plate. PhD thesis, University of Glasgow.

Full text available as:
[thumbnail of 10646901.pdf] PDF
Download (31MB)


Limb deformities were successfully produced in skeletally immature lambs following contralateral limb hip excision arthroplasty. In order to determine the growth potential of the ovine skeleton prior to induced pelvic limb imbalance a preliminary study of normal epiphyseal fusion in comparable lambs has been performed. A detailed investigation of the angular bone deformities that were produced was then Undertaken. In particular, the growth cartilage of deformed bones was studied and both decalcified and undecalcified sections of bone extremities prepared. Undscalcified sections permitted microradiographs to be produced and as sequential bone labels were administered the effect on longitudinal bone growth of limb imbalance could be assessed. In addition, angiography was performed and differences were visualised in the blood supply adjacent to the growth plate following induced limb imbalance. Although pronounced angular deformities were produced, in addition, a dramatic increase in bone torsion was encountered in tibiae. In metatarsi there was normally minimal or no torsion in control animals but those undergoing deformity exhibited marked axial rotation. By means of static load bearing and gait analysis observations, the aetiology of induced bone deformities has been investigated. It is postulated that asymmetrical growth plate loading occurs and, as a result, abnormal endochondral bone growth is produced.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: J R Campbell
Keywords: Medicine, Developmental biology
Date of Award: 1979
Depositing User: Enlighten Team
Unique ID: glathesis:1979-72627
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 11 Jun 2019 11:06
Last Modified: 11 Jun 2019 11:06

Actions (login required)

View Item View Item


Downloads per month over past year