Problems in the treatment and assessment of patients with thyrotoxicosis: A clinical and laboratory study

Bremner, William Fraser (1976) Problems in the treatment and assessment of patients with thyrotoxicosis: A clinical and laboratory study. PhD thesis, University of Glasgow.

Abstract

This thesis falls logically into 5 sections. SECTION A outlines the present understanding of the aetiology of thyrotoxicosis and discusses presently available tests of thyroid function regarding their relevance to the Trial of Iodine-125 therapy. This is important as accuracy of assessment of thyroid status has markedly improved since the inception of the Trial in 1968. The currently available treatments for thyrotoxicosis are discussed with particular attention paid to their drawbacks. The problem of posttherapy hypothyroidism is emphasised., SECTION B outlines the experimental and theoretical basis for the iodine-125 trial and describes in detail the design and results of the trial in 15GG patients. Reasons for the failure of this isotope to reduce the incidence of post-therapy hypothyroidism are discussed and further experimental evidence (from the author) is adduced. The validation of a TRH-induced thyrotoxicosis model in the rat as an approach to the human condition is described, SECTION C describes experimental tissue culture studies of adrenoreceptor blocking drugs which have rapidly attained the status of a major adjuvant therapy in treating thyrotoxicosis SECITION D This section discusses the need for a test or tests of body response to thyroid hyper-or hypofunction and describes a new test of thyroid status; systolic time interval measurements. Zinc losses in hyperthyroidism are described and the potential value of such measurements discussed. SECTION E concentrates on the cardiac complication of hypo- and hyperthyroidism with investigations of lipid abnormalities in hypothyroid patients and electronmicroscopic studies of hyperthyroid rat hearts.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Advisers: E M McGirr; W R Greig
• Keywords: Medicine
• Date of Award: 1976
• Depositing User: Enlighten Team
• Unique ID: glathesis:1976-72668
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 11 Jun 2019 11:06
• Last Modified: 11 Jun 2019 11:06
• URI: https://theses.gla.ac.uk/id/eprint/72668