Hormone production by the human ovary

Kader, Abdul Samad bin Abdul (1978) Hormone production by the human ovary. PhD thesis, University of Glasgow.

Abstract

Sensitive, specific, precise and accurate radioimmunoassays have been developed for A, DHT, and T. These assays were applied to determine the profiles of these hormones in daily samples from normally menstruating women. Plasma samples were also obtained at hysterectomy from peripheral and ovarian veins; where practical samples were obtained from the veins draining both the active and the contralateral ovaries. In this study a larger number of such samples had been obtained than has been reported previously and in addition the stage of the menstrual cycle was better documented than in previous reports by using as many parameters as possible - menstrual history, ovarian and endometrial histology, and peripheral hormone levels. Samples were obtained from 40 patients, of reproductive age, whose conditions did not affect ovarian function and in whom the stage of the menstrual cycle could be accurately assessed. Samples were also obtained from a number of patients with disorders which would affect their reproductive cycles. From the 40 patients with normal ovarian function a composite menstrual cycle was constructed. Using the newly developed radioimmunoassays and pre-established methods the levels of FSH, LH, PRL, P 170HP, OE2, A, DHT and T were determined in all plasma samples. The hormone assays demonstrated that:- (i) the peripheral levels from the"normally cycling" patients were within the normal ranges obtained from volunteers. (ii) the Graafian Follicles produced P, 170HP,A, DHT, T, and OE2. The amount of these compounds produced varied with the stage of development of the Graafian Follicles. (iii) the corpus luteum also produced all of the hormones which follicles produced [c.f. (ii) above]. The total production of steroid hormones was greatest during the MS stage of the cycle. (iv) at certain stages of the cycle particularly the MS the contralateral ovary also produced small but significant quantities of hormones - A, DHT, T and OE2. (v) In the pathological and unphysiological conditions examined the ovarian production of hormones was unpredictable but allowed an insight into ovarian function in such patients. On the basis of these results conclusions were drawn, as to the production of hormones by the human ovary, and the contributions made to this by the different ovarian structures, throughout the menstrual cycle.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Advisers: M C Macnaughton; J RT Coutts
• Keywords: Endocrinology
• Date of Award: 1978
• Depositing User: Enlighten Team
• Unique ID: glathesis:1978-72771
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 11 Jun 2019 11:06
• Last Modified: 11 Jun 2019 11:06
• URI: https://theses.gla.ac.uk/id/eprint/72771