Studies of the alteration of carbohydrate, fat and brain amine metabolism in man in health and disease

Chalmers, Robert John (1975) Studies of the alteration of carbohydrate, fat and brain amine metabolism in man in health and disease. MSc(R) thesis, University of Glasgow.

Abstract

1. Nine patients with Huntington's chorea and one with chorea were admitted to a double-blind cross-over trial of tetrahenazine, thiopropazate and placebo. 2. Thiopropazate (P<0.01) and tetrahenazine (P< 0.001) both significantly controlled chorea. 3. The administration of tetrahenazine was accompanied by a pronounced rise (P <0.001) in the concentration of H.V.A. in c.s.f., suggesting increased cerebral dopamine metabolism. 4. The effect of thiopropazate was much smaller and was not statistically significant. 5. It is suggested that tetrahenazine is the drug of first choice for the suppression of chorea in patients with Huntington's chorea.

• Item Type: Thesis (MSc(R))
• Qualification Level: Masters
• Additional Information: Adviser: R H Johnson
• Keywords: Neurosciences
• Date of Award: 1975
• Depositing User: Enlighten Team
• Unique ID: glathesis:1975-72842
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 11 Jun 2019 11:06
• Last Modified: 11 Jun 2019 11:06
• URI: https://theses.gla.ac.uk/id/eprint/72842