Reactions of adult mouse tissues and embryo organ homografts on exposure to carcinogens

Peacock, Philip M (1965) Reactions of adult mouse tissues and embryo organ homografts on exposure to carcinogens. MD thesis, University of Glasgow.

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The accepted standard methods of testing substances for their toxic properties were examined under the following general headings:- Skin Painting, Injection Methods, Implantation Methods. From published work it was evident that many factors influenced the results obtainable by any given procedure. Animal experiments were therefore devised to investigate the influence of these factors. These Studies involved large numbers of animals from which considerable histological material was examined. The results so obtained made it possible to systematize and standardize many of the methods to a degree previously unrecorded. Thereafter comparative studies were made of the improved techniques as tests for carcinogenicity. As a series of test substances fifteen polycyclic aromatic hydrocarbons were used. These were tested blind and only identified after completion of the experiments. It was found that the implant method personally evolved gave the best results as a test for carcinogens. Exploration of the potential of this method of embryo organ homografting has shown that in each case the objectives of the application have been fulfilled. It is felt that this work has produced a very adaptable and sensitive experimental procedure for which there are many applications.

Item Type: Thesis (MD)
Qualification Level: Doctoral
Additional Information: Adviser: A DT Govan
Keywords: Toxicology, Analytical chemistry
Date of Award: 1965
Depositing User: Enlighten Team
Unique ID: glathesis:1965-72934
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 11 Jun 2019 11:06
Last Modified: 11 Jun 2019 11:06

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