A study of intestinal innervation using nicotine and reserpine

Mackenna, Beverly Robertson (1962) A study of intestinal innervation using nicotine and reserpine. PhD thesis, University of Glasgow.

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This thesis describes in vitro investigations into the autonomic innervation of the rabbit colon. The innervated rabbit colon preparation, described by Garry & Gillespie (1995, 1955) and lengths of innervated rabbit ileum, were used for these studies. The thesis mainly comprises an investigation of the following three phenomena. First, the present studies show that if nicotine is added in vitro to the isolated rabbit colon in small concentrations, it causes relaxation of the smooth muscle. Secondly, reserpine ('Serpasil': Ciba) which is known to discharge catechol amines from sympathetic nerves and chromaffin tissue, causes not simply abolition of the inhibitory response of the rabbit colon to sympathetic nerve stimulation, but indeed a reversal of the inhibition to contraction. Thirdly, having thus reversed the response to sympathetic nerve stimulation from inhibition to contraction by reserpine treatment, it is possible to restore the original inhibition by soaking the preparation in catechol amines or dopa. Part I of the thesis comprises an investigation of the first of these phenomena and Part II comprises mainly an investigation of the other two phenomena.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: R C Garry
Keywords: Neurosciences
Date of Award: 1962
Depositing User: Enlighten Team
Unique ID: glathesis:1962-73530
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jun 2019 08:56
Last Modified: 14 Jun 2019 08:56
URI: https://theses.gla.ac.uk/id/eprint/73530

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