Biochemical aspects of antibody production

Moffat, George E (1968) Biochemical aspects of antibody production. PhD thesis, University of Glasgow.

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The work presented in this thesis was directed towards developing a clearer understanding of some of the biochemical aspects of antibody production. The systems employed were rabbit-anti-bovine serum albumin (BSA) for studies on the specific activity of DNA polymerase, and rat-anti-sheep red blood cells (SHBC's) for polyribosome studies. Some rabbits were rendered tolerant to BSA by the intraperitoneal infection of this protein at birth. The establishment of tolerance was confirmed by antigen elimination tests in the mature animal. Comparative studies were made on the specific activity of DNA polymerase from the spleens and appendices of normal untreated rabbits, rabbits undergoing a primary or secondary response to BSA and rabbits previously rendered tolerant to BSA. The results obtained indicated that in the case of the splenic polymerase activity was observed by the immunization procedures. Increased activity was observed on days

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: J N Davidson
Keywords: Biochemistry, Immunology
Date of Award: 1968
Depositing User: Enlighten Team
Unique ID: glathesis:1968-73802
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 14 Jun 2019 08:56
Last Modified: 14 Jun 2019 08:56

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